If you keep finding yourself in the same bad business deals guess what the constant is...you. The same goes if you keep trying the latest marketing fad, or watching your best people leave the company. Something needs to change, and that something is you.
Take a look at the consistent patterns that take place in those situations. Make a list of what to avoid and what to look for in the ideal situation next time. Make sure you don't get fooled again.
What mistakes seem to continually plague your business? What can you do to change the situation?